四逆汤防治冠心病心绞痛的临床研究

Clinical Study on "Sini" Decoction in Treating Stenocardia for Coronary Heart Disease

目的:观察四逆汤防治冠心病心绞痛的临床疗效。方法:将辨证为阳虚或寒凝的63例冠心病心绞痛患者随机分为四逆汤治疗组(35例)和消心痛对照组(28例),比较两组在症状、ECG、心肌耗氧、心功能等方面的疗效。结果:四逆汤在改善冠心病心绞痛临床症状、ECG、降低心绞痛发作频率、减少硝酸甘油用量等方面与消心痛相似,但在降低心肌耗氧、改善心功能方面,四逆汤较优。结论:四逆汤可用于冠心病心绞痛的防治,是阳虚寒凝型冠心病心绞痛的有效方药。

Objective: To observe clinical effect of 'Sini' decoction on stenocardia for coronary heart disease. Methods:63 cases of stenocardia for coronary heart disease with deficiency of yang or cold syndrome were randomly divided into 'Sini' decoction group (therapeutic group, 35 cases) and isosorbide dinitrate group (contrast group, 28 cases) . Drug effects of the two groups were compared by clinical symptoms, electrocardiogram (ECG), myocardial oxygen consumption and cardiac function. Results; Similar to isosorbide dinitrate, 'Sini' decoction could improve clinical symptoms and ECG, decrease frequency of stenocardia and dose of nitroglycerin on stenocardia for coronary heart disease. But 'Sini' decoction had better effects on reducing myocardial oxygen consumption and improving cardiac funrtion than isosorbide dinitrate. Conclusion; 'Sini' decoction can treat stenocardia for coronary heart disease with deficiency of yang or cold syndrome.