河南林县Alzheimer病危险因素的巢式病例对照分析

A Nested Case-Control Study of Alzheimer Disease in Linxian, North China

目的 :探讨河南林县阿尔茨海默病 (AD)的危险因素。方法 :采用年龄 (± 2岁 )、性别和乡别匹配的巢式病例对照研究方法分析 15年前的生活习惯、心理社会因素、躯体检查史和疾病史等对AD发生的影响作用。结果 :多因素模型中 ,高血压值OR =1 971、吃发霉蔬菜OR =1 767,皮肤病和贫血的疾病史OR值分别为 0 2 2 7和 0 5 34 ,且均存在显著性意义 ;高血压值的人群归因危险度为 2 8 3% ,与AD之间趋势检验P <0 0 0 0 2。结论 :在林县地区AD的发生中 ,高血压和吃发霉蔬菜为危险因素 ,而皮肤病和贫血的疾病史为保护因素 ;血压值与AD之间存在剂量 -反应关系。

Objective: To identify potential risk factors for Alzheimer Disease (AD) in a nutrition deficient population in Linxian county, north China Method: The controls were matched to the index cases on sex, age ((2 years) and residential area, and information obtained from the baseline interview and examination in 1985 Factors related to AD, included life style, psychological and social issues, and results of physical examinations and general medical history Univariate logistic regression and multvariate logistic regression were used and statistical testing was done at the two-tailed alpha level of 0 05, also odds ratios (OR) and 95% CI were calculated Result: There were significant associations between AD and hypertension (OR=1 97, 95% CI: 1 10-3 54), mould vegetable diet (OR=1 77 95% CI: 1 11-2 81), skin disease (OR=0 28, 95% CI: 0 09-0 57), and anemia (OR=0 53, 95% CI: 0 28-1 04) The population attributable risk of hypertension was 28 3% The Trend test between blood pressure and AD showed significance (P<0 01) Conclusion: Hypertension and moldy vegetable diet are risk factors for AD while history of skin disease and anemia are protective factors in Linxian The association between blood pressure and AD is dose related Smoking and drinking have no relation to AD in this area