高血压与阿尔茨海默病关系的初步探讨

The Relation between Hypertension and Alzheimer Disease

目的 :探讨高血压与阿尔茨海默病 (AD)的关系 ,以及AD患者患病前后血压的变化。方法 :对 16488名队列人群 16年前的收缩压和舒张压值进行分层后比较不同层人群AD患病率的差别 ,并对 30 1名AD患者患病前后的血压进行比较。结果 :在收缩压不同的四个分层人群中 ,各层AD患病率有显著的差别(χ2 =15 1 9,P =0 0 0 0 ) ,高压组最高 (5 5 1% ) ,低压组最低 (0 5 8% )。在舒张压不同的四个分层中 ,各层AD患病率有显著的差别 (χ2 =10 3 5 ,P =0 0 0 0 ) ,高血压组的患病率最高 (4 72 % ) ,低压组最低(1 0 8% )。对于高血压组的AD患者 ,患病前后收缩压变化无显著性意义 ,而舒张压显著性下降 (P <0 0 1)。结论 :高血压与AD存在密切的联系 。

Objective: To investigate the relationship between hypertension and Alzheimer disease (AD) Method: Comparing the prevalence of AD in population (n=16488) stratified by systolic or diastolic blood pressure (BP) and comparing BP of 301 AD patients before and after the onset of AD Result: When stratified by systolic BP, there was significant difference of prevalence of AD in different groups (χ 2=151 9, P<0 01) with the highest prevalence in hypertension group (5 51%) and lowest in hypotension group (0 58%) Similar results were got when stratified by diastolic BP, that was highest prevalence of AD in hypertension group (4 72%) and lowest in hypotension group (1 08%), the difference was significant (χ 2=103 5, P<0 01) For AD patients with hypertension, there was no significant difference of systolic BP before and after onset of AD, but their diastolic BP decreased significantly after AD onset Conclusion: AD and hypertension have some association in our study, the mechanism for this phenomena is unclear