摘要
以奶山羊为实验动物 ,按体重灌服氟化钠复制奶山羊氟病模型 ,通过对血清细胞因子的检测 ,进一步探讨氟病的发生机理。结果表明 :氟可引起白细胞介素 2 (IL 2 )、白细胞介素 6 (IL 6)含量降低 ;肿瘤坏死因子 (TNF)含量升高。证明氟引起细胞因子含量的变化是氟致机体免疫抑制的机制之一。
Twelve goats were divided into two groups. Group Ⅰ was treated as control and group Ⅱ was fed with sodium fluoride (NaF) orally according to their bodyweight. After 12 months of fluoride dosing, goats of group Ⅱ showed clinical signs of fluorosis and their blood samples were taken for analysis. The results showed as follows: Fluoride decreased the contents of inteleukin 2 (IL?2) and inteleukin 6 (IL?6), significantly increased the contents of tumour necrosis factor (TNF) compared with group Ⅰ. It is suggested that fluoride reduce immune function and create the conditions for various malignancies in fluorosis.
出处
《畜牧与兽医》
北大核心
2003年第3期9-11,共3页
Animal Husbandry & Veterinary Medicine
