新生儿败血症94例病原及药物敏感试验分析

Analysis of pathogen and drug sensitivity test in 94 cases of neonatal septicemia.

目的 探讨新生儿败血症的病原及药物敏感情况 ,以指导治疗 ,提高疗效。方法 对我院近 5年来收住的94例血培养阳性 ,确诊为新生儿败血症的病原菌和抗菌药物敏感性进行分析。结果 病原菌以葡萄球菌为主 ,共 69例( 73 40 % ) ,其中表皮葡萄球菌 2 6例 ( 2 7 66% )、溶血性葡萄球菌 14例 ( 14 89% )、金黄色葡萄球菌 12例 ( 12 77% )。其次为大肠埃希菌 10例 (占 10 63% )。青霉素、氨苄青霉素基本耐药 ,含 β 内酰胺酶抑制剂的药物 (氨苄西林舒巴坦、头孢三、四代抗生素 )、亚胺培南、万古霉素、丁胺卡那霉素、环丙沙星敏感率高。结论 根据血培养药敏结果选用敏感抗菌药物 ,可减少细菌耐药性的产生 。

Objective To study the pathogen and drug sensitivity test of neonatal septicemia to direct clinical treatment. Methods The pathogen and the sensitivities of anti-biotic drugs were analysed in 94 cases with positive blood cultures in the past in our hospital 5 years.Results The pathogen was mainly staphylococcus in 69 cases,of which 26 were staphylococcus epidermis(27.66%),14 cases were staphylococcus hemolyticus(14.89%),12 were staphylococcus aureus(12.77%),But 10 cases were Escherichia coli(10.63%).Penicillin and Ampicillin were almost drug-resistant,the sensitivities of those drugs such as β-lactamas drugs(Sulbactam-Ampicillin and Cephalosporin Ⅲ and Ⅳ),vancomycin,kanamycin,ciprofloxacin were higher.Conclusion To choose sensitive antibiotic drugs based on the drug sensitivity tests may decrease the occurrence of drug-resistant bacteria and increase the clinical curative effects.