积极干预亚临床型佝偻病的双盲对照研究

Double-blind Compared Study on Active Intervention of Sub-clinical Stage of Rickets

目的 对进行干预的和未干预治疗的亚临床型佝偻病进行比较和评估。方法 对 6个月～ 2岁的健康儿童进行登记和血清骨碱性磷酸酶 (BLAP)测定 ,将BLAP >2 0 0IU/L的亚临床型佝偻病儿童随机分为治疗组和对照组 ,对治疗组进行干预治疗 6个月后复查和统计 ,2组比较佝偻病和呼吸道感染的发病情况。结果 亚临床型佝偻病发病率为 2 3 8% ;佝偻病发病情况 :2组儿童中佝偻病症状相比较 ,多汗、夜惊发生率有高度显著性差异 (P <0 0 1) ,而烦躁不安这一症状的差异不如前 2者明显 (P <0 0 5 ) ;在呼吸道感染发病情况中 ,上呼吸道感染发生率有显著性差异 (P <0 0 1) ,而下呼吸道感染无显著性差异 (P >0 0 5 )。结论 及时发现和治疗亚临床型佝偻病不仅可以降低越冬后因光照不足而发展为佝偻病的机率 。

Objective To compare and assess the interventional and non-interventional rickets in sub-clinical stage. Methods The healthy children from 6 months to 12 year-old were registered at the end of fall and BLAP was detected. The sub-clinical stage of rickets whose BLAP>200IU/L were divided into test group and control group randomly. The interventional treatment was taken in test group for 6 months and the statistics were analyzed. The rickets and respiratory infection in two groups were compared. Results The incidence rate of sub-clinical rickets was 23.8%. The incidence of night terrors and hidrosis was significantly difference between two groups (P<0.01). The fidgety and agitation was P<0.05 in two groups. There was significantly difference in upper respiratory tract infection with P<0.01 but not in lower respiratory tract infection P>0.05. Conclusion The investigation and treatment on time of sub-clinical stage of rickets might reduce the incidence rate of rickets in winter due to less sunshine and could decrease the incidence of URI.