1Anderluh M, Dolenc MS. Thrombin receptor antagonists; recent advances in PAR-1 antagonist development[J]. Curr Med Chem,2002,9:1229-1250.
2Lee KB, Kawai N,Kim S, et al.Mechanisms of edema formation after intracerebral hemorrhage:effects of thrombin on cerebral blood flow,blood-brain barrier permeability, and cell survival in a rat model[J] .J Neurosurg, 1997,86: 272-278.
3Lee KR, Colon GP, Beta AL, et al. Edema from intracerebral hemorrhage:the role of thrombin[J] .J Neurosurg, 1996,84:91-96.
4Vaughan PJ,Cunningham DD. Regulation of protease nexin-1 synthesis and secretion in cultured brain cells by injury-related factors[J] .J Bid Chem, 1993,268:3720-3727.
5Donovan FM, Pike CJ, Cotman CW, et al. Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities[J]. J Neurosci, 1997,17:5316-5326.
6Xi G,Keep RF,Hua Y, et al. Attentuation of thrombin-induced brain edema by cerebral thrombin preconditioning [J]. Stroke, 1999, 30:1247-1255.
7Xi G, Hua Y, Keep RF, et al. Activation of p44/42 mitogen activated protein kinases in thrombin-induced brain tolerance[J]. Brain Res,2001,895 : 153-159.
8Yang GY, Betz AL, Chenevert TL, et al. Experimental intracerebral hemorrhage:relationship between brain edema,blood flow, and Hoodbrain barrier permeability in rats[J] .J Neurosurg, 1994,81:93-102.
9Weinstein JR, Gold SJ, Cunningham DD, et al. Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA[J].J Neurosci, 1995,15 : 2906-2919.
10Lee KR, Betz AL, Keep RF, et al. Intracerebral infusion of thrombin as a cause of brain edema[J] .J Neurosurg, 1995,83:1045-1050.
