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New Eudesmane and Eremophilane Derivatives from Laggera Alata 被引量：3

New Eudesmane and Eremophilane Derivatives from Laggera Alata
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摘要 From the aerial part of Laggera alata, a novel eremophilanoid (1) as well as two new eudesmanoids (2-3) were isolated. Their structures were elucidated by 2D-NMR technique and X-ray diffraction studies. The cytotoxic activities of these sesquiterpenes were also investigated. From the aerial part of Laggera alata, a novel eremophilanoid (1) as well as two new eudesmanoids (2-3) were isolated. Their structures were elucidated by 2D-NMR technique and X-ray diffraction studies. The cytotoxic activities of these sesquiterpenes were also investigated.
作者 QunXiongZHENG ZhaoJunXU XianFengSUN FrancoiseGUERITTE MicheleC
机构地区 DepartmentofBiochemistry DepartmentofTraditionalChineseMedicineandNaturalDrugResearch I
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2003年第4期393-396,共4页 中国化学快报（英文版）
基金 This work was financed in part by the Life Sciences Special Fund of Chinese Academy of Sciences supported by the Ministry of Finance (STZ-00-24) the Yunnan Province Foundation of Applied Basic Research (2000C0072M) Chine-France PRA BT01-02 and the
关键词 Laggera alata SESQUITERPENE eremophilanoid eudesmanoid X-ray diffraction cytotoxicity. Laggera alata, sesquiterpene, eremophilanoid, eudesmanoid, X-ray diffraction, cytotoxicity.
分类号 R284 [医药卫生—中药学]
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  • 1[1]Y. Zhao, J. M. Yue, Y. N. He, Z. W. Lin, H. D. Sun, J. Nat. Prod., 1997, 60, 545 (and the literature cited therein).
  • 2[2]Y. Zhao, J. M. Yue, Z. W. Lin, J. K. Din, H. D. Sun, Phytochemistry, 1997, 44, 459 (and the literature cited therein).
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  • 7[7]13C-NMR spectral data of compounds 1-3. (1): C-1 - C-15: 126.0, 201.9, 42.9, 37.3, 41.7, 30.0, 33.8, 30.3, 40.7, 146.3, 170.2, 177.6, 123.6, 19.3, 15.7; (2): C-1 - C-15: 37.1, 22.8, 124.9, 131.0, 143.2, 121.6, 38.5, 26.3, 38.2, 31.3, 145.5, 126.0, 172.6, 23.4, 20.1; (3): C-1 - C-15: 38.8, 18.2, 38.7, 76.5, 76.8, 36.7, 38.3, 27.6, 35.2, 38.8, 148.4, 171.2, 122.4, 25.6, 26.8. 1H-NMR spectral data of compounds 1-3. (1): 5.94 (br s, 1H, H-1); 2.34 m, H-3; 2.40 m, H-3'; 2.36 m, H-4; 2.41 m, H-6α; 1.98 m, H-6β; 2.63 (dddd 1H J=11.0, 11.0, 4.5, 4.5Hz, H-7α); 2.00 m, H-8; 2.76 (dddd 1H J=13.5, 11.0, 11.0, 4.5Hz, H-8' ); 1.70 (ddd 1H J=13.5, 11.0, 4.5Hz, H-9α); 1.92 (ddd 1H J=13.5, 4.5, 4.5Hz, H-9'); 6.26 (br s, 1H H-13); 5.70 (br s, 1H H-13'); 1.16 s, H-14; 1.05 d (6.0), H-15. (2): 1.60 m, H-1α; 2.05 m, H-1(; 2.06 ddd (12.5, 4.5, 4.5), H-2α; 2.64 ddd (12.5, 11.0, 4.5), H-2(; 5.56 br s, H-3; 5.39 br s, H-6; 3.42 ddd (10.0, 7.5, 3.0), H-7α; 1.44 m, H-8α; 1.40 m, H-8(; 1.54 m, H-9α; 1.56 m, H-9(; 6.34 br s, -13; 5.70 br s, H-13'; 1.00 s, H-14; 1.79 s, H-15. (3): 1.02 ddd (13.5, 4.8, 4.8), H-1α; 1.76 ddd (13.5, 11.0, 4.8), H-1'; 1.90 (dddd 1H J=13.5, 12.0, 7.0, 4.5Hz, H-2α); 1.68 (dddd 1H J=13.5, 7.0, 4.5, 4.5Hz, H-2'); 1.38 d(dd 1H J=13.5, 6.8, 4.5Hz); 2.68 (ddd 1H J=13.5, 12.0, 6.8Hz, H-3'); 2.06 (dd 1H J=13.5, 4.5Hz, H-6α); 1.48 (dd J=13.5, 12.0Hz, H-6'); 3.49 (dddd 1H J=12.0, 12.0, 4.5, 4.5Hz, H-7α); 1.18 m, H-8α; 1.72 m, H-8'; 1.70 (ddd 1H J=13.2, 9.8, 3.5Hz, H-9α); 1.28 (ddd 1H, J=13.2, 3.5, 3.0Hz, H-9'); 6.10 (br s, H-13); 5.56 (br s, H-13'); 0.99 s, H-14; 1.26 s, H-15.

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Chinese Chemical Letters
2003年 第4期

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