卵巢上皮癌治疗及预后影响因素研究

A Study of Influence Factors on Treatment and Prognosis in Patients with Epithelial Ovarian Cancer

目的演探讨影响卵巢上皮癌治疗与预后的因素。眼方法演对1991年1月至2000年12月10年间在哈尔滨医科大学三院治疗的383例卵巢上皮癌进行回顾分析,术后化疗以PAC方案为主(顺铂、环磷酰胺、表阿霉素),采用SAS软件统计,对资料进行单因素及多因素COX逐步回归分析。眼结果演383例卵巢上皮癌1年、3年、5年的生存率分别为75.56%、39.28%、30.09%。Ⅰ～Ⅳ期中位生存期分别为78、55、21、17个月穴平均25个月雪。化疗疗程数>6者比<6者预后好(P<0.01)。无残留或残留病灶<2cm者比>2cm者预后好(P<0.01)。眼结论演卵巢上皮癌预后与临床分期、有无残留癌及术后化疗疗程数等相关。

To investigate the influence factors on treatment and prognosis in patients with ep ithelial ovarian cancer.A retrospective study of383cases with ovarian epithelial carcinoma in the Third Harbin Medical College Affiliated Hospital from Jan.1991to Dec.2000was carried out.PAC(cyclophosphamide,adriamycin,cisplatin)regimen was administered postoperatively,COX model was used to evaluate the prognostic factors of the disease at univariate and multivariate levels using SAS software.The1-,3-,and5-year survival rates were75.56%,39.28%,30.09%respectively.The median survival of stageⅠ～Ⅳwere78,55,21,and17months respectively(overall25months).The prognosis of those who received more than6courses of chemotherapy,or with no residual tumor,or residual tumor<2cm,was better than those with less than6courses of chemotheraly or with residual tumor>2cm.[Conclusion]The prognosis of patients with epithelial ovarian cancer is related to the clinical stage,presence of residual tumor and number of postoperative chemotherapy courses.