血小板阻聚药物中间体N-环己基-5-氯丁基-1H-四氮唑的合成(英文)

Synthesis of N-cyclohexyl-5-(4'-chlorobutyl)-1H-tetrazole as an Important Intermediate of Platelet Aggregation Inhibitor Drugs

以δ 戊内酯和环己胺为原料合成了抗血小板聚集药物西洛他唑的重要中间体N 环己基 5 氯丁基 1H 四氮唑 。

N cyclohexyl 5 (4' chlorobutyl) 1H tetrazole was synthesized by a convenient process from δ valerolactone and cyclohexylamine. Appropriate cyclocondensation reagent and phase transfer catalyst were selected. The yield of product is 78%. The product is an important intermediate for producing drugs of blood platelets aggregation inhibitors.