病毒载量和T淋巴细胞计数在HIV感染者临床治疗疗效观察中的应用

Clinical study on treatment of HIV infected persons based on viral load detection and CD4 + T lymphocyte counting

目的 研究病毒载量检测和CD4 + 计数在评价人类免疫缺陷病毒 (HIV)感染者疗效中的应用效果。方法 对HIV感染者临床病例 73例进行了实验室和临床观察 ,其中包括 6例鸡尾酒治疗病例、36例中药试验性治疗病例及 31例未进行治疗的感染者。主要实验室指标包括血浆病毒载量及T淋巴细胞亚群计数。结果 在进行治疗后 3个月时联合治疗组的病毒载量明显低于其他两组 ,并且在其后保持在很低的水平 ,CD4 + 计数水平明显高于其他两组并在其后持续升高。在整个观察期间 ,中药治疗组的病毒载量检测和CD4 + 计数水平与未治疗组差异无显著性 ,但在临床症状观察中中药治疗组较未治疗组有明显改善。结论 病毒载量检测和CD4 + 计数试验是评价抗HIV治疗疗效的有效方法。

Objective To study the usage of viral load and CD4 + cell count methods in evaluating the effects of clinical treatment in HIV infected people. Methods Totally 73 cases of HIV infected persons were studied with clinical observation and laboratory examinations,six cases were treated with cocktail therapy,36 cases with chinese herbs and the other 31 cases were untreated.Results The results indicated that the viral load levels in cocktail therapy group were significantly lower than the other two groups within 3 months and then kept at very low level.The CD4 +T lymphocyte levels showed a significant increase after 3 months and kept rising up.The chinese herb group,however,had no significant difference in viral load level and CD4 + T lymphocyte level as compared with untreated group.But in clinical observation chinese herbs showed the effect of improving clinical status in some cases. Conclusion The authors conclude that the viral load and CD4 + count are efficient methods in clinical evaluation of HIV treatment,especially in routine anti\|HIV therapy.As for the chinese herbs treatment,these two monitors did not reflect changes in clinical status.