山东省枣庄市乙型病毒性肝炎流行病学调查

Epidemiological feature of hepatitis B in Zaozhuang city,Shandong Province

目的 了解枣庄市人群中乙型肝炎的流行特征。方法 于 2 0 0 0年采用随机分层抽样 ,调查 312户家庭的 96 3人 ,以RIA法检测HBsAg、抗 HBs和抗 HBc。结果 HBsAg、抗 HBs、抗 HBc和HBV标化流行率分别为 7.0 8%、37.5 6 %、4 1.35 %和 4 4 .37%。HBsAg流行率男性高于女性 (P <0 .0 5 ) ,城区高于农村 (P <0 .0 1) ,在不同年龄及职业人群中差异无显著性 (P >0 .0 5 )。抗 HBs、抗 HBc和HBV感染率有随年龄增长而递增的趋势 (P <0 .0 1)。HBV总感染率男性高于女性 (P <0 .0 5 ) ,农村高于城市 (P <0 .0 5 )。结论 枣庄市人群HBV感染率较高 ,应积极采取预防和控制措施 ,减少发病。

Objective To study the prevalence and the epidemiological feature of hepatitis B in the population of Zaozhuang and the seroepidemiology of hepatitis B virus infection. Methods HBsAg, anti HBs and anti HBc were detected in 963 sera collected from 312 families by RIA, which were selected by multistage and stratified cluster sampling. Results The results indicated that the standardized positive rates of HBsAg, anti HBs and anti HBc were 7.08% , 37.56% and 41.35%,respectively and the standardized prevalence rate of hepatitis B virus infection was 44.37%. The positive rate of HBsAg was higher in male subjects and in the urban area groups than those in female subjects ( P <0.05) and in rural area groups ( P <0.01), respectively. There was no significant difference in the positive rate of HBsAg among all age groups and occupation groups ( P >0.05). The positive rates of anti HBs and anti HBc and infective rate of hepatitis B virus increased with age. The infective rate of hepatitis B virus was higher in male subjects and in rural area groups than those in female subjects ( P <0.05) and in urban area groups ( P <0.05), respectively.Conclusion The HBV infective rate of population was higher in Zaozhuang city;measures of prevention and control should be taken actively and effectively.