β-七叶皂甙钠对皮瓣缺血再灌注损伤的保护作用

Protective Effect of β-Aescin on Ischemia and Reperfusion Injury of Skin Flap

目的观察 β-七叶皂甙钠对皮瓣缺血再灌注损伤的保护作用。方法建立兔皮瓣缺血再灌注损伤动物模型。实验分对照组和治疗组。测定皮瓣丙二醛、内皮素、细胞线粒体钙含量和组织湿/干重比值 ,观察皮瓣成活情况。结果使用 β-七叶皂甙钠后 ,皮瓣各项生化指标与对照组相比明显降低 ,皮瓣存活面积显著提高。结论 β-七叶皂甙钠可减轻皮瓣缺血再灌注损伤 。

Objective To observe the protective effect of β_Aescin on ischemia and reperfusion injury of skin flap.Methods The experimental model of ischemia and reperfusion injury of skin flap was produced in the rabbits which were divided into control group and treatment group. The levels of MDA,ET, mitochondria calcium and wet/dry skin flap were measured, while the survival area of skin flap was observed.Results The biochemical indexes of treatment group were obviously lower as compared with those of control group (P<0.01,P<0.05), while the survival area of skin flap of treatment group was significantly higher than that in the control group(P<0.01).Conclusions The experiment revealed that β_Aescin might have protective effect on skin flap during ischemia and reperfusion injury.