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高血压患者冠状动脉储备功能的临床研究 被引量:1

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摘要 目的探讨老年高血压患者冠状动脉储备功能 (CFR)。方法冠状动脉造影正常的高血压患者76例 ,无左心室肥厚 (LVH)32例 (Ⅰ组 ) ,合并LVH44例 (Ⅱ组 ) ,正常对照组26例 (Ⅲ组 )。检查前停服所有血管活性药物至少5个半衰期 ,3d内未服用茶碱类药物。三组受检者隔日分别静脉注入99mTc -MIBI30mci行静态、运动心肌核素断层显像 ,潘生丁以0.84mg/kg剂量缓慢静脉注射 ,于注射前、后即刻2、4、6min测量血压 ,记录18导朕心电图。结果心肌核素显像 :Ⅰ组运动后单光子发射型计算机断层仪 (ECT)呈缺血性改变3例 (9.4% ) ,Ⅱ组运动后ECT呈缺血性改变11例 (25.0 % ) ,有反向再充填现象2例 (4.5 % ,P<0.05)。心电图潘生丁试验 :Ⅰ组阳性1例 (3.1 % ) ,可疑阳性3例(9.4 % ) ;Ⅱ组阳性7例 (15.9 % ) ,可疑阳性9例 (20.5 % ,P<0.05)。心电图潘生丁试验阳性或可疑阳性伴ECT缺血性改变 :Ⅰ组 :无 ;Ⅱ组8例 (18.2 % ,P<0.01)。正常对照组心肌核素显像及潘生丁试验均无异常。结论高血压患者存在不同程度CFR下降 ,合并LVH尤为明显 ,其原因可能与冠状动脉微循环结构及功能异常有关。
出处 《中国微循环》 2002年第5期315-315,共1页 Journal of Chinese Microcirculation
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