恶性肿瘤病人血清细胞角蛋白19片段等四联检结果分析

Combined Determination of Serum CYFRA21-1,TSGF,CA50, CEA for Malignant Tumor

目的 :探讨恶性肿瘤病人血清细胞角蛋白 19片段 (CYFRA2 1- 1)、恶性肿瘤特异性生长因子(TSGF)、糖链抗原 (CA5 0 )、癌胚抗原 (CEA)的含量改变在恶性肿瘤诊断中的意义。方法 :连续收集一年中各类恶性肿瘤病人共 6 89例 ,同时设立非恶性肿瘤组和健康体检组作为对照 ;采用放免或生化等方法检测血清CYFRA2 1- 1、TSGF、CA5 0、CEA的含量 ,然后分析比较。结果 :恶性肿瘤组的血清CYFRA2 1- 1、TSGF、CA5 0、CEA含量分别为 6 6 4± 14 2 5 (ng/ml)、79 73± 15 94 (U/ml)、12 37± 30 5 8(U/ml)、14 2 0± 38 76 (ng/ml) ,均明显高于非恶性肿瘤组和健康体检组 ,差异有高度显著性 (p <0 0 1)。CYFRA2 1- 1、TSGF、CA5 0、CEA测定的敏感度分别为 35 3%、6 9 1%、8 0 %、12 0 % ,测定的特异度分别为 91 7%、83 3%、98 6 %、93 1% ;四项联检的阳性率明显提高。对于各类恶性肿瘤 ,TSGF含量均高于对照组 ,差异有高度显著性 (p <0 0 1) ,检测的阳性率一般 >6 0 % ;大部分恶性肿瘤的血清CYFRA2 1- 1水平亦升高 ,与对照组相比差异有显著性 (p <0 0 5 )。结论 :通过恶性肿瘤 6 89例分析 ,联合检测血清CYFRA2 1- 1、TSGF、CA5 0、CEA含量能提高恶性肿瘤诊断的阳性率 ;CYFRA2 1- 1和TSGF测定在肿瘤临床诊断和?

Objective To explore the diagnostic significance of the levels of serum cytokeratin 19 fragments (CYFRA21-1)? tumor specific growth factor (TSGF)? carbohydrate antigen (CA50)? carinoembryonic antigen (CEA) in patients with malignant tumor. Methods The levels of serum CYFRA21-1? TSGF? CA50? CEA were measred by immunoradiomentric assay or biochemical determination in 689 patients with malignant tumor, the controls comprise 40 patients without malignant tumor and 32 persons for health examination. Results The levels of serum CYFRA21-1? TSGF? CA50? CEA were 6 64±14 25(ng/ml)? 79 73±15 94(U/ml)? 12 37±30 58(U/ml)? 14 20±38 76(ng/ml) respectively in the group of malignant tumors, and were significantly higher than those in the controls ( p <0 01). The sensitivity of measurement of CYFRA21-1? TSGF? CA50? CEA were 35 3%? 69 1%? 8 0%? 12 0% and the specificity were 91 7%? 83 3%? 98 6%? 93 1% respectively. The positive rate were significantly increased when combined determinations of serum CYFRA21-1? TSGF? CA50? CEA. The levels of serum TSGF were higher significantly in all kinds of malignant tumor then those in the controls ( p <0 01), and the positive rates was more than 60% generally. And for CYFRA21-1, the serum levels of patients with many different kind of malignant tumors were also significantly higher then those in the controls ( p <0 01). Conclusion Combined determination of CYFRA21-1? TSGF? CA50? CEA can increase the positive rate of diagnosis for malignant tumor, moreover, the measurement of TGSF and CYFRA21-1 is valuable in both clinic diagnosis and mass screening.