五种恶性肿瘤血清IGF-Ⅱ水平及意义

Levels and Clinical Significance of Serum IGF-Ⅱ in Patients with Five Kinds of Malignant Tumors

目的 :探讨恶性肿瘤患者血清IGF -Ⅱ水平及临床意义。方法 :采用放射免疫分析法检测胃癌、肺癌、肝癌、卵巢癌、子宫内膜癌患者血清IGF -Ⅱ ,并与肝硬化、子宫肌瘤和正常对照组进行比较。结果 :胃癌、肺癌、肝癌患者血清IGF -Ⅱ水平明显高于正常对照组 (p<0 0 1) ,肝硬化患者明显高于正常对照组 (p <0 0 1) ,但与肝癌患者比较则明显降低 (p <0 0 1) ;卵巢癌、子宫内膜癌、子宫肌瘤患者与正常对照组比较均无显著性差异 (p >0 0 5 )。结论 :血清IGF -Ⅱ测定对于子宫内膜癌、卵巢癌和子宫肌瘤患者不具临床应用价值 ,但有助于胃癌、肺癌、肝癌及肝硬化患者病情观察和预后判断。

Objective To study the levels and clinical significance of serum IGF-Ⅱ in patients with malignant tumor. Methods Levles of serum IGF-Ⅱ were detected in patients with gastric cancer, lung cancer, liver cancer, avarian corcino ma and endometrial carcinoma, by radioimmunoassay levels in patients with hepatic cirrhosis, uterine myoma and normal controls were also determined for comparism. Results The levels of serum IGF-Ⅱ in patients with gastric cancer, lung cancer and liver cancer were significantly higher than those in normal controls ( p <0 01), Levels of IGF-Ⅱ in patients hepatic with cirrhosis were higher than normal controls ( p <0 01) but were lower than liver cancer significantly ( p <0 01). The levels of serum IGF-Ⅱ in patients with endometrial carcinoma, ovarian carcinoma and uterine myoma were not significantly different from normal controls ( p >0 05). Conclusion The determination of serum IGF-Ⅱ has no clinical significance in patients with endometrial carcinoma, ovarian carcinoma and uterine myoma but it could be useful to judge the severrity and evaluate the prognosis in patients with gastric cancer, lung cancer, liver cancer and cirrhosis.