微型电化学氧传感器用于模拟高空缺氧环境中氧分压的测量

The Needle-electrochemical Micro-sensor for the Measurement of pO_2 in High Altitude

以自制的微型电化学氧传感器和多通道生物活体氧分压分析仪为研究工具 ,在低压氧舱内模拟不同高度下的低压缺氧环境 ,通过测量血管周隙及其旁开氧分压的值 ,发现随着外界氧的减少 ,血管周隙及其旁开的氧也随之减少 ;同时动态在位地监测血管周隙及其旁开的氧分压在模拟高度上升或下降过程中的变化情况 ,实时反映出生物体对外界环境中氧变化的响应 .

The needle-electrochemical micro-sensor and the multi-channels oxygen analyzer were developed to monitor the pO 2 of the perivascular space (PVS) and the tissue sideward in diverse high altitudes, which were simulated in the low-pressure chamber. The pO 2 in the PVS and in the tissue sideward decreased when the altitude increased. At the same time, the fluctuation of the pO 2 in the PVS and the tissue sideward were monitored during the increasing and decreasing of the altitude in the in vivo and in situ experiments.