扶正化瘀胶囊治疗慢性乙型肝炎疗效观察

Effective Observation of Fuzheng Huayu Capsules Treatment for Chronic Hepatitis B

目的:探讨扶正化瘀胶囊治疗慢性乙型肝炎的效果。方法:慢性乙型肝炎42例随机分为扶正化瘀胶囊治疗组和安慰剂对照组,治疗组28例,对照组15例,两组均每次1.5克,每日3次,连服6个月。动态观察临床表现、生化指标和肝纤维化指标。结果:治疗组治疗3、6个月ALT复常率分别为59.26％(16/27例)和66.67％(18/27例),对照组则分别为33.33％(5/15例)和53.33％(8/15例),治疗组均高于对照组。扶正化瘀胶囊对于血清肝纤维化指标(透明质酸、Ⅳ型胶原)也有改善。用药3个月治疗组和对照组血清肝纤维化指标的显效率分别为48.15％、13.33％,用药6个月显效率分别为59.26%、20%,3、6个月两组比较均有显著差异(P<0.01)。结论:扶正化瘀胶囊能降低ALT,改善或延缓肝纤维化的进程。

Objective: To explore the therapeutic effects of Fuzheng Huayu Capsule treatment for chronic hepatitis B. Meth-ods: 42 patients with chronic hepatitis B were enrolled and randomized into treated group and control group, the 28 patients in the treat-ed group treated with Fuzheng Huayu Capsule, the 15 patients in the control group treated with placedo. The dose of two groups was l. 5g each tirae, three times per day for 6 consecutive months. Clinical and serum biochemical parameters as weU as semm fibrotic mark-ers were observed dynamically and compared. Results: After treated 3 and 6 months, the recovered rate of ALT of the treated group were respectively 59.26% (16/27) and 66.67% (18/27), these of the control group were 33.33% (5/15) and 53.33% (8/15). The recovered rate of ALT of the treated group is higher than that of the control group. Fuzheng Huayu Capsule can also improve the serum fibrotic parameters(Hyaluronic acid and collagen type Ⅳ) . After treated 3 months, the markedly effective rate of the treated group and the control were respectively 48.15% and 13.33%. After treated 6 months, the markedlv effective rate were respectively 59.26% and 20% . The markedlv effective rate of the treated group was obviously higher than that of the control group (P < 0.01). Conclusion: Fuzheng Huayu Capsule can decrease serum ALT, improve or delay li ver fibrosis process.