对老年高血压病患者手术前后部分血小板活化功能的探讨

The change of CD62P/CD41/CD63 in elderly patients with hypertension before and after operation

目的 观察手术对老年高血压病患者血小板活化功能的影响。方法 选择 110例老年择期手术患者 ,按有无高血压病分成高血压病组和对照组 ,分别于手术前和手术后 30min抽肘静脉血送实验室 ,用流式细胞分析仪测定CD6 2P、CD6 3、CD4 1含量。结果 术前高血压病组患者的CD6 2P、CD6 3、CD4 1较对照组明显增高 ,差异有显著性意义(P <0 .0 5 ) ;术后 2组患者的CD6 2P、CD6 3、CD4 1较术前均明显增高 ,其中高血压病组更高 ,差异有显著性意义 (P<0 .0 1)。结论 手术更易激活老年高血压病患者的血小板功能 ,增加血栓性并发症的发生率 ,应注意围手术期的抗凝措施。

Objective To assess the effect of operation on the activity of platelet in elderly patients with hypertension.Methods One hundred and ten ASA Ⅱ～Ⅲ elderly patients undergoing elective operation were divided into two groups:hypertension group(group H,n=55) and control group (group C,n=55).By means of flow cytometric method,CD62P(P selectin),CD63(GP53) and CD41(GPⅡb) contents in peripheral blood were studied in these patients before and after operation.Results The expressions of CD62P/CD63/CD41 on the platelet membrane surface after surgery were statistically higher than those before. The CD62P/CD63/CD41 contents in group H increased more significantly than in group C.Conclusion The results suggest that surgical operation may obviously promote the platelet activity in the elderly patients, especially in the elderly patients with hypertension.