摘要
目的 探讨老年人急性心肌梗死 (AMI)患者外周循环肿瘤坏死因子 α(TNF α)和白细胞介素 10 (IL 10 )的变化及辛伐他汀对TNF α和IL 10的作用。方法 测定 39例老年AMI患者 (AMI组 )、2 0例老年陈旧性心肌梗死 (OMI)患者 (OMI组 )及 2 0例正常老年人 (正常人组 )血清TNF α和IL 10浓度。 39例AMI患者入院后随机分为辛伐他汀组和对照组 ,治疗前、治疗后 1周和 6周测定血清TNF α和IL 10浓度。结果 AMI组TNF α、IL 10水平明显高于OMI组 ;OMI组TNF α水平明显高于正常人组 ;正常人组血清IL 10未检测到。辛伐他汀组和对照组经治疗后 1周、6周TNF α水平均显著下降 ,6周后辛伐他汀组TNF α水平显著低于对照组。辛伐他汀组和对照组IL 10水平 6周后均显著降低 ,但两组差异无显著性意义。结论 辛伐他汀具有降低AMI患者血清TNF α水平的作用 ,对IL
Objective To investigate the changes of tumor necrosis factor alpha (TNF α) and interleukin 10 (IL 10) in elderly patients with acute myocardial infarction (AMI) and the effects of simvastatin.Methods Serum TNF α and IL 10 levels were measured with the method of ELISA in 39 AMI patients, 20 old myocardial infarction (OMI) patients and 20 normal controls.The 39 AMI patients were randomized into simvastatin group (n=20) and control group (n=19).Serum TNF α and IL 10 levels were examined before and after 1 week and 6 weeks of treatment.Results The serum levels of TNF α and IL 10 in the AMI group were significantly higher than those in the OMI group (P<0.0001). The serum level of TNF α in the OMI group was significantly higher than that in the normal controls (P<0.05). The serum IL 10 was not detected in the normal controls. The serum TNF α level was significantly decreased after 1 week(P<0.001) and 6 weeks (P< 0.0001 )of treatment in simvastatin group and control group.The serum TNF α level in the simvastatin group was significantly lower than that in the control group after 6 weeks(P<0.05)of treatment.The serum IL 10 level significantly decreased after 6 weeks of trearment(P<0.0001)in simvastatin group and control group. There was no significant difference between simvastatin group and control group in the serum IL 10 level after 6 weeks(P>0.05). Conclusions Simvastatin can modulate the level of serum TNF α in AMI patients,but can not modulate the level of serum IL 10.
出处
《中华老年心脑血管病杂志》
CAS
2003年第1期33-35,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
