妊高征患者β-HCG与AFP关系的研究

The Study of the Relationship Between β-HCG and AFP in Pregnancy-Induced-hypertension

目的 :探讨妊娠高血压综合征 (妊高征 )患者血清β HCG与甲胎蛋白 (AFP)水平变化及其相互关系。方法 :采用化学发光法测定 90例妊高征和 10 0例正常中、晚期妊娠妇女血清 β HCG与AFP值。结果 :妊高征孕妇血清 β HCG值明显升高 ,与正常孕中晚期妇女相比 ,差异显著 (P <0 .0 1) ,且随病情加重其数值进行性升高 ;重度妊高征血AFP水平与正常中、晚期孕和轻、中度妊高征相比明显升高 ,差异显著 (P <0 .0 1) ;重度妊高征时 β HCG与AFP水平呈一定相关性(r=0 .5 315 ) ,轻、中度妊高征时β HCG与AFP水平无相关性。 结论 :β HCG升高可作为预测妊高征与判断病情轻重的指标 ,而AFP在重度妊高征的预测与判断病情轻重方面才有意义 ,联合检测 β

Objective:To evaluate the changes in serum β HCG and AFP in pregnancy induced hypertension(PIH) and to analyse the correlation between them.Methods: 90 patients with PIH were matched with 100 normal the second and third trimester singleton pregnant women.Serum β HCG and AFP were measured by the chemoluminescence.Results: Serum β HCG levels in PIH were significantly higher than that of normal group( P <0.01),parallel to the disease severity,but serum AFP only in severe PIH were significantly higher than that of normal group and in mild,moderate PIH( P <0.01).There were definite correlation between β HCG and AFP in severe PIH(r=0.5315),no association with mild and moderate PIH.Conclusions: The increase of β HCG maybe used as a detecting index for providing PIH and evaluating the degree of severity,whereas AFP only had significance in severe PIH.Combination of measurement of serum β HCG with AFP can improve the sensitivity of evaluating the disease.