233例妊娠期肝内胆汁淤积症临床分析

Clinical Analysis of 233 Cases with lntrahepatic Cholestasis of Pregnancy

目的 :探讨妊娠期肝内胆汁淤积症 (ICP)的发生率、诊断及处理。方法 :对本院近 2年发生的 2 33例ICP病例分治疗组 (12 8例 )和未治组 (10 5例 )进行回顾性分析。结果 :治疗组围产儿死亡率 ,宫内窘迫 ,新生儿窒息明显少于未治组。结论 :对ICP的早期诊断、早期治疗 ,适时终止妊娠是降低围产儿死亡率的关键 。

Objective:To discuss the incidence,diagnosis and management of Intrahepatic cholestasis of Pregnancy(ICP).Methods: 233 cases with ICP in our hospital for nearly 2 years,128 in the treatment groups and 105 in the non treatment groups,were analyzed retrospectively. Results: In treatment groups,the incidence of perinatal mortality,fetal distress and asphyxia of newborn infants were significantly lower than those in non treatment groups( P <0.01).Conclusions: To diagnose and treat ICP early,appropriate opportunity for delivery is cardinal procedure to reduce perinatal mortality and postpartum hemorrhage.