摘要
目的 测定替米沙坦片中替米沙坦的含量。方法 采用紫外分光光度法 ,在 2 96nm波长处测定 ,空白辅料无干扰。结果 替米沙坦浓度在 4× 10 -3 ~ 16× 10 -3 mg·ml-1范围内与吸光度有良好的线性关系 (r =0 .9999)。平均回收率为 99.75 %。重复性试验的 RSD =0 .37%。结论 所建立的方法简便、灵敏、专属、准确 ,可供替米沙坦片的含量测定。
OBJECTIVE To establish a UV spectrophotometry method to determine telmisartan in tablets.METHODS Telmisartan was determined at 296 nm and the excipients do not interfer with the determination.RESULTS There was a good linear relationship between concentration and absorbance within the range of 4×10 -3 -16×10 -3 mg·ml -1 (r=0.9999). The average recovery was 99.75% and RSD=0.37%.CONCLUSION The method was sensitive, specific, accurate and simple. It was suitable for measuring the contents of telmisartan in the tablets.
出处
《华西药学杂志》
CAS
CSCD
2003年第1期61-63,共3页
West China Journal of Pharmaceutical Sciences