呼吸氦氧混合气最大呼气流速-容积曲线在慢性阻塞性肺病的应用价值

Application of the maximal expiration flow volume cure breathing helium-oxygen mixture in COPD

目的 探讨呼吸氦氧混合气最大呼气流速 -容积曲线 (MEVCHe O2 )在慢性阻塞性肺病 (COPD)诊断、治疗指导及康复效果判定中的临床应用价值。方法 测定COPD患者呼吸氦氧混合气前后MEVC曲线 ,并设对照组进行比较。结果 两组MEVCair和MEVCHe O2 结果即吸入氦氧混合气前后比较差异均有显著性 (P <0 .0 5 ) ;两组MEVCHe O2 结果皆较MEVCair结果有不同程度的增加 ,但增加百分率除FVC有显著性外 (P <0 .0 5 ) ,其余结果差异均无显著性 (P >0 .0 5 ) ;COPD组呼吸He O2 前后MEVC比较差异也无显著性。结论 未能证实呼吸氦氧混合气体能有效检出小气道病变、判断其病变是否可逆及推断气道阻塞的部位 ,其对COPD诊断、治疗指导及康复效果判断的作用不大。

Objective To investigate the clinical application of the maximal expiration flow volume cure(MEVC) breathing helium -oxygen mixture in the clinical diagnosis, treatment and rehabilitation in COPD. Methods MEVC were detected before and after breathing the helium-oxygen mixture in COPD patients and healthy control, and a comparison was made between the COPD group and the control group.Results MEVC airand MEVC He-O 2were significantly different before and after breathing the helium-oxygen mixture in both the COPD group and the control group(P<0.05). MEVC He-O 2elevated to a certain degree when compared with MEVC airin both groups, but the differences had no statistical significances except that in DFVC(P<0.05).Conclusion The application of MEFV breathing helium-oxygen mixture can not evaluate the small airway function, detecting the reversibility and the site of airway obstruction. The MEVC with helium-oxygen mixture inhalation has no significances on the clinical diagnosis, treatment and rehabilitation of COPD.