血清高甲胎蛋白水平变化与慢性乙型肝炎预后的关系

The relationship between the level of serum alpha-fetoprotein and the progress of chronic hepatitis B

目的 探讨血清甲胎蛋白 (AFP)水平变化与慢性乙型肝炎预后的关系。方法 对 86例慢性乙型肝炎患者采用双抗体夹心法测定AFP水平。其中 47例同时用PCR法测定HBVDNA浓度。采用相关分析法分析AFP与血清丙氨酸转氨酶 (ALT)和血清门冬氨酸转氨酶 (AST)以及AFP与HBVDNA之间的关系。另外 10例患者给予拉米夫定治疗 ,并比较治疗前后AFP水平变化。结果 AFP的升高与肝功能损害程度和慢性乙肝患者病毒复制呈高度正相关 ,且用拉米夫定治疗对乙肝病毒复制有抑制作用 ,同时亦有AFP恢复。结论 观察AFP变化有利于慢性乙肝患者预后的判断。

Objective To investigate the relationship between high alpha-fetoprotein (AFP) levels in patients with chronic hepatitis B and prognosis of them. Methods Levels of AFP as well as ALT and AST were measured by ELISA in 86 patients with chronic hepatitis B. HBV DNA level was detected by PCR in 47 cases at the same time. The relationship between AFP and ALT, AST and HBV DNA was analyzed by correlation analysis. 10 patients were treated with lamivudine, whose levels of AFP were measured before and after therapy.Results AFP was closely related to the damage of liver function and replication of HBV in chronic hepatitis B. Lamivudine inhibits replication of HBV and induces the recovery of AFP. Conclusion Observation of serum AFP is a valuable prognostic factor in patients with chronic hepatitis B.