老年恶性肿瘤放化疗后真菌感染临床分析

Deep Fungal Infection after Radiotherapy or Chemotherapy: A Clinical Analysis Old Malignant Tumor Patients Suffering

目的 老年恶性肿瘤患者放、化疗后并发真菌感染危险因素诊断及防治。方法 通过对 4 2例真菌感染患者现状调查 ,对疑有真菌感染患者进行分泌物和体液的培养。结果 真菌感染占同期肿瘤科医院感染病例的11 6 7% ,感染部位以口腔感染占首位 ,其次为肺部、肠道 ;真菌感染类型主要是白色念株菌感染、克柔念株菌感染等 ;感染发生与患者原发病、放疗、化疗及激素的应用、抗生素应用等有关。结论 早期诊断、早期治疗是减少真菌感染的发生、缩短平均住院日、降低医疗费用的关键。

OBJECTIVE To evaluate risk factors of deep fungal infection after radiotherapy or chemotherapy in old malignant tumor patients,and their preventive and therapeutic measures.METHODS Forty two deep fungal infection cases were investigated by culturing secretion and the body fluid samples.RESULTS Deep fungal infection which was detected in 11.67% of infection cases in the Department of Oncology,took place more frequently in oral cavity,and then in lung and intestinal tract,accompanied by primary tumor, radiotherapy,chemotherapy,hormone and antibiotic applications with Candida albicans and Klebsiella Pneumoniae as principal infection agents. CONCLUSIONS Early diagnosis and treatment are the key to reduce deep fungal infection, hospitalization duration and medical expenses.