重组人碱性成纤维细胞生长因子在烧伤创面中的应用

APPLICATION OF RECOMBINANT HUMAN BASIC FIBROBLAST FACTOR IN BURN WOUND

目的 :观察重组人碱性成纤维细胞牛长因子 (rh -bFGF)对烧伤创面愈合的影响。方法 :2 0 0 0年 2月～2 0 0 1年 12月局部清创后随机对 80例Ⅱ°烧伤创面和 8例烧伤后残余肉芽创面作为治疗组 ,用rh -bFGF喷雾剂以 15 0AU/cm进行局部喷涂 ,无菌敷料覆盖包扎。 80例早期烧伤创面采用自身对照法行常规治疗 ,观察同一深度、面积相近的创面的愈合时间 ,同期随机另选择 8例烧伤后残余肉芽创面者行常规治疗作为对照 ,观察创面愈合时间、创面局部及全身反应情况。结果 :治疗组创面愈合时间明显提前 ,经统计学处理 ,有显著性差异 (P <0 .0 5 )。结论 :rh -bFGF有明显促进烧伤创面愈合的作用。

Objective:To observe the effect of Recombinant Human Basic Fibroblast Growth Factor (rh-bFGF) on the healing of burn wound.Methods:From 2000 to 2001 ,eighty patients with second degree burn wounds and eight patients with postburn granulation tissue wounds were adopted in this study,and these patients were treated with rh-bFGF in the way of sprinkling locally(150AU/cm). The eighty patients with early burn wounds were adopted as the self control group and another eight patients with postburn granulation tissue wounds were adopted as the control group which were routinely treated. The healing time of wounds and the local and systemic reactions were observed.Results:The healing time of wounds was shorter with rh-bFGF than that of the control group and there was significant difference between the two groups( P <0.05).Conclusion:Rh-bFGF can obviously promote the healing of burn wound.