秋水仙碱治疗三叉神经痛的浓度筛选实验研究

Experimental study on selection of colchicines concen trations to cure the trigeminal neuralgia

目的 筛选秋水仙碱治疗三叉神经痛的适当浓度。方法 选择 4个浓度的秋水仙碱注射于大鼠眶下神经干。观察注射后 5天内痛觉敏感征发作时 ,大鼠胫前肌肌电图 (EMG)发放情况。记录同一侧和对照侧EMG各项指标。结果 统计学分析表明 ,秋水仙碱各浓度间及与对照组间差别有统计学意义。结论 经过对临床症状和EMG比较 ,0 0 8%秋水仙碱的治疗作用比较理想。

Objective To select a suitable concentration of colchicines in order to cure the trigeminal neuralgia.Methods Four kinds of concentrations of colchicines were injected into the infraorbital nerve of rats respectively.The representations of the hyper irritability outbreak were recorded with the electromyogram(EMG) of the anterior tibial muscle discharged separatedly at the 1,2,5 and 6 days.The EMG of one group was con trasted to others in order to analyze which concentration of colchicines was proper. Results The result indicated that there was statistically significant difference among the four concentrations of colchicines and between colchicines groups and control groups( P <0.001).Conclusion It is clear that 0.08% colchicines is suitable for treating trigeminal neuralgia.