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奥曲肽预防肝纤维化形成的实验研究 被引量:5

Experimental study on the preventive effect of Octeotide on liver fibrosis
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摘要 目的 探讨奥曲肽对实验性大鼠肝纤维化形成的影响。方法 采用大鼠免疫损伤性肝纤维化模型 ,实验动物分为 :正常对照组、病理模型组及奥曲肽预防组 ,对肝功能、病理肝纤维化分级和肝组织羟脯氨酸含量进行比较。结果 奥曲肽预防组与病理模型组相比 ,其肝功能有明显改善 ,肝纤维化分级明显减低 ,羟脯氨酸含量明显减少。结论 奥曲肽对实验性大鼠肝纤维化的肝细胞损伤及肝功能有明显的保护作用 ,对实验性肝纤维化形成有明显预防作用。 Objective To study the effect of Octeotide on liver fibrosis. Methods The therapeutic effect of Octeotide was observed on rat fibrotic model induced by albumin complex. Indexs of liver activity(AST?ALP?T-Bil and ALB) , the severity of liver fibrosis and hepatic Hydroxyproline contents was measured during the processes. Results Numerical value of AST,ALP and T-Bil in Octeotide treatment group were lower than those in model group,but ALB was higher. Liver fibrosis was significant lightened and hepatic Hydroxyproline contents was reduced by using Octeotide. Conlusion Octeotide may protect the rat liver from hepatic cell injury in the processes of liver fibrosis, and may increase the antifibrotic effect in practice.
出处 《中华肝胆外科杂志》 CAS CSCD 2003年第2期100-102,共3页 Chinese Journal of Hepatobiliary Surgery
关键词 奥曲肽 预防 肝纤维化 肝硬化 Drug evaluatin Octeotide Liver fibrosis Hydroxyproline
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