人类细小病毒B_(19)感染与新生儿高间接胆红素血症

Relationship between human parvovirus B_(19) infection and neonatal indirect hyperbilirubinemia

目的 探讨人类细小病毒B1 9(HPVB1 9)感染与新生儿高间接胆红素血症 (新生儿高胆 )发生的关系。 方法 对13 6例新生儿高胆及 12 3例正常新生儿用聚合酶链反应技术进行血液HPVB1 9 DNA的检测。 结果 13 6例新生儿高胆的患儿HPVB1 9 DNA阳性者 48例 ,阳性率 3 5 3 % ,12 3例正常新生儿HPVB1 9 DNA阳性者 12例 ,阳性率 9 8% ,两组之间阳性率比较有非常显著性差异 (χ2 =2 3 7,P <0 0 0 5 )。 结论 新生儿高胆的发生与HPVB1

Objective To study the relationship between human parvovirus (HPVB\-\{19\}) infection and neonatal indirect hyperbilirubinemia.Methods Nested polymerase chain reaction was used to detect HPVB\-\{19\} DNA on blood from 136 neonates with indirect hyperbilirubinemia and 123 normal neonates.Results 48 of 136 cases with neonatal indirect hyperbilirubinemia and 12 of 123 normal neonates were HPVB\-\{19\} DNA positive with a positive rate of 35\^3% and 9\^8% respectively,which were significantly different between two groups(χ\+2=23 7, P <0 05).Conclusion The high incidence of neonatal indirect hyperbilirubinemia may be correlated with HPVB\-\{19\} infection.