新疆地区3512例新生儿染色体突变率的分析

Analysis of the chromosomal mutation rate among 3512 newborns in Xinjiang

目的 :研究新疆地区新生儿群体中染色体突变率。方法 :脐带血淋巴细胞培养和染色体G显带技术。结果 :在 3 5 12例新生儿中发现 8例染色体异常。其中常染色体三体性 3例 ,其突变率为 4.2 7× 10 -4 ;性染色体三体性 1例 ,其突变率为 2 .84×10 -4 ;染色体缺失 3例 ,其突变率为 4.2 7× 10 -4 ;相互易位 1例 ( 19/2 1) ,其突变率为 1.42× 10 -4 。结论 :新疆地区汉民族新生儿群体中染色体突变率低于国外。这是由于选择性迁移后形成的群体构成、规模和繁殖结构中的低血缘所致。

Objective:To study the chromosomal mutation rate of the newborns in Xinjiang.Methods:Lymphocytic cells of omphalo-blood was cultured and analyzed .Results:Eight cases of chromosome anomaly from 3 512 newborns were detected. Among them ,there were 3 cases of autosomal trisomy(mutation rate 4.27×10 -4), one sex chromosomal trisomy(mutation rate 2.84×10 -4), three chromosomal deletion ( mutation rate 4.27×10 -4), one reciprocal translocation (mutation rate 2.84×10 -4).Conclusion:The chromosomal mutation rate of Han dynasty in Xinjiang is lower than that of the overseas. It may be due to the low blood relationship of colony structure, formula and breeding structure from the selective migration. The pressure of the environment acts at the leading role.