心血管病昼夜节律的流行病学研究

Epidemiological investigation of circadian rhythm of cardiovascular disease

目的 研究心血管病发作或加重的昼夜节律。方法 采用流行病学调查方法。结果 ①心血管病定时发作于 2 1:0 0～ 1:0 0时达到峰值 (2 6.48% ) ,在 5 :0 0～ 9:0 0时达到第二高峰 (2 1.69% ) ,11:0 0～ 13 :0 0时发作最少(2 .5 5 % ) ,整体呈双峰型节律。②男性组与女性组昼夜各时段心血管病发作或加重的变化趋势不同 (P <0 .0 1)。心血管不同心功能状况的发作昼夜节律不同 (P <0 .0 1) ,心功能I级好发于上午 (43 .4% ) ;心功能Ⅱ级发作无昼夜节律 ,心功能Ⅲ级在上半夜为高发时段 (5 0 .0 % ) ,心功能IV级亦好发于上半夜 (5 2 .99% )。结论 心血管病的发作或加重存在昼夜节律 ,心功能状况不同其节律亦不同 ,建议临床制定治疗和护理方案时应参考其昼夜节律。

Objective\ To explore the circadian rhythm of cardiovascular disease during onset or development.Methods\ Epidemiological investigation was used. Results\ ①Cardiovascular disease got to its peak value at 21:00～1:00 (26.48%),to the second peak value at 5:00～9:00,and to its lowest value at 11:00～13:00 (2.55%) and the whole rhythm showed double peak type .②The onset and development of circadian rhythm of cardiovascular disease were different between female and male groups (P<0.01); circadian rhythm of different classes of cardiovascular disability was different (P<0.01). 43.4% of cardiovascular disability class Ⅰ happened in forenoon; class Ⅱ had no significant circadian rhythm,and most of class Ⅲ and Ⅳ came down with the illness before midnight (50.0%,52.99%) .Conclusion\ The attacking and worsening of cardiovascular diseases have circadian rhythm . Circadian rhythm of different clases of cardiovascular disability is different. It is suggested that circadian rhythm should be considered in clinical treatment.