9-肟基-3-酮基-6-O-甲基红霉素的合成

Synthesis of 9-Oximido-6-O-methyl-3-oxo-erythromycin

以红霉素为原料 ,经肟化、苄基化、甲基化、水解、氧化和氢化还原等 6步反应 ,制得 9-肟基 - 3-酮基 - 6 - O-甲基红霉素。总收率 41%。

Oximido-6-O-methyl-3-oxo-erythromycin was synthesized from erythromycin A by oximation, protection, methylation, hydrolysis, oxidation and deprotection in an overall yield of 41%.