2-巯基-5-甲氧基-1H-苯并咪唑的制备

Preparation of 2-Mercapto-5-methoxybenzimidazole

以对乙酰氨基酚为原料 ,经甲基化、硝化、水解得到 4-甲氧基 - 2 -硝基苯胺 ,Raney- N1 催化下以水合肼还原后 ,再与乙基黄原酸钾环缩合制得奥美拉唑重要中间体 2 -巯基 - 5 -甲氧基 - 1H-苯并咪唑 ,总收率 6 9%。

Mercapto-5-methoxybenzimidazole was synthesized from p-acetaminophenol by methyl- ation, nitration and hydrolysis to give 2-nitro-4-methoxyaniline, which was reduced by hydrazine hydrate using Raney-Ni as catalyst and followed by cyclocondensation with potassium ethyl xanthate in one pot to give the title compound with an overall yield of 69%.