摘要
采用中和法制备咪喹莫特脂质体 ,研究了其体外经皮扩散行为并与咪喹莫特乳膏进行比较。制得的脂质体平均粒径为 85 5 nm,跨距为 1.6 5 ,能经皮缓慢扩散 ,皮层的局部贮药量比之乳膏有增加 ,可减少药物全身吸收。
Imiquimod liposomes were prepared using neutralization method and the in vitro transdermal diffusion of imiquimod in liposomes and cream was compared. The results showed that the liposomes had an average diameter of 850nm with a span of 1.65. Compared with the cream, the liposomes tend to improve the local storage of imiquimod in the skin and may decrease the systematic absorption.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2003年第2期73-75,共3页
Chinese Journal of Pharmaceuticals