盐酸左氟沙星对小鼠全身感染保护效果的研究

The protecting effect of levofloxacin hydrochloride on the systemic infection in mice

目的:探讨和评价盐酸左氟沙星对小鼠全身感染的保护作用。方法:采用小鼠960只。随机分为96组,分别用一定量的大肠杆菌、金葡球菌、绿脓杆菌、福氏痢疾杆菌感染小鼠,各组感染后即刻静脉注射或口服不同剂量的盐酸左氟沙星和氧氟沙星。测试盐酸左氟沙星对4种细菌感染小鼠的保护作用。结果:盐酸左氟沙星对上述4种细菌感染小鼠体内保护静注ED_(5O)分别为0.359mg/kg,5.848mg/kg,22.894mg/kg,0.371mg/kg;口服ED_(5O)分别为0.554mg/kg,8.129mg/kg,28.895mg/kg,0.492mg/kg。结论:盐酸左氟沙星对小鼠全身感染保护作用静注优于口服,并优于氧氟沙星。

Objective:To study and evaluate the protecting effect of levofloxacin hydrochloride on systemic infection in mice. Methods :960 mice were used,and divided randomly into 96 groups. Certain amount of E. coli,S. aureus,P. aeruginosa and S. flexneri were administered respectively into the mice and all of them were infected. Immediately after being infected,each group of mice were given different doses of intravenous or oral levofloxacin hydrochloride and of loxacin, in order to determine the protective effect of levofloxacin hydrochloride on the mice infected with these four bacteria. Results: The intravenous injection of ED50 of levofloxacin hydrochloride to the bacteria strains was 0.359mg/kg,5.848mg/kg,22.894mg/kg and 0. 371mg/kg respectively;and ED50through the oral route was 0. 554mg/kg,8. 129mg/kg,28. 895mg/kg and 0. 492mg/kg respectively. Conclusion :The protecting effect through intravenous injection of levofloxacin hydrochloride on systemically infected mice is more superior to that of the oral route,and also better than ofloxacin.