地洛他定与氯雷他定治疗荨麻疹临床对比观察

Observation of clinical efficacy on treating urticaria with desloratadine and loratadine

目的:评价地洛他定治疗荨麻疹的疗效和安全性。方法:将 50例荨麻疹患者随机分为试验组地洛他定5mgl日1次和对照组氯雷他定10mgl日1次,疗程均为7天(急性荨麻疹)或14天(慢性荨麻疹)。结果:治疗组与对照组在起效时间及疗效比较无显著性差异(P=0.971和P=0.051)。两组病例不良反应相似且轻微。结论:地洛他定是治疗荨麻疹安全有效的药物。

Objective:To evalute the efficacy and safty of desloratadine against urticaria. Methods: Fifty patients with urticaria were randomly assigned to receive either 5mg of desloratadine daily or lOmg of loratadine daily for 7 days (acute urticaria) and 14 days (chronic urticaria). Results : There were no statistically significant differences between the two groups in terms of time in taking effect and clinical efficacy(P = 0.971 and P = 0.051). Adverse effects were similar and mild in the two groups. Conclusion :It is indicated that desloratadine is well - tolerated and effecitive for the treatment of urticaria.