糖皮质激素对小梁网的作用研究进展

Research advances of glucocorticoid effects on human trabecular meshwork

应用糖皮质激素可引起眼压升高 ,它与原发性开角型青光眼关系密切。糖皮质激素对小梁网的作用可作为一个良好模型用于研究青光眼的发病机制。糖皮质激素对小梁网的作用是多方面的 ,它包括细胞外基质、细胞膜、细胞骨架及细胞核的多重变化。

The administration of glucocorticoids can elevate intraocular pressure in some individuals. There is suggestive evidence linking glucocorticoids with the development of glaucoma. Glucocorticoid effects on the human trabecular meshwork can be used as a model system in which to study glaucomatous damage to the trabecular meshwork. Glucocorticoids cause multiple effects on the human trabecular meshwork including changes in extracellular matrix metabolism, organization of the cytoskeleton, and changes in gene expression and cell function. New discoveries on the molecular mechanism of glucocorticoid receptor action provide new opportunities to study the possible role of this receptor in the development of glaucoma.