脂糖舒对2型糖尿病大鼠胰岛素抵抗的影响

Effect of Zhitangshu on the insulin resistance in rats with type 2 diabets mellitus

目的 观察脂糖舒 (ZTS)对 2型糖尿病大鼠胰岛素抵抗的改善作用。方法 分别对 2型糖尿病胰岛素抗性模型两组大鼠灌服不同剂量的ZTS(每日 1次 ) ,连续 9周 ,同时以健康大鼠 (正常对照组 )、二甲双胍和格列齐特作对照 ,进行糖耐量试验 ,测定血浆葡萄糖 (Glu)、胰岛素 (Ins)、甘油三脂 (TG)、游离脂肪酸(NEFA)、总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL c)和高密度脂蛋白胆固醇 (HDL c)含量并称体重和脂肪组织重量 ,计算胰岛素抵抗指数 (IRI)。结果 脂糖舒抑制病鼠体重和脂肪组织重量增长以及降糖降脂 (TG、NEFA及LDL)和降IRI作用优于格列齐特 (P <0 0 1)。与二甲双胍比较 ,脂糖舒降NEFA作用较强 (P <0 0 5 ) ,降IRI作用与二甲双胍相当 (P >0 0 5 ) ,且脂糖舒降IRI作用呈剂量依赖关系。结论 脂糖舒明显改善 2型糖尿病的胰岛素抗性。

Objective To observe the effect of Zhitangshu(ZTS) on the insulin resistance in rats with type 2 diabetes mellitus.Methods The diabetic rats were treated respectively with ZTS,metformin hydrochloride tablets(MHT) and gliclazid tablets(GCT) for 9 weeks and compareal with the heathy rats.The contents of insulin(Ins),glucose(Glu),triacylglycerol(TG),non-esterified fatty acid(NEFA),total cholesterol(TC),low density lipoprotein cholesterol(LDL-c),high density lipoprotein cholesterol(HDL-c) of these rats were detected and glucose tolerance,body weight and fat of rats were tested,insulin resistance index(IRI) was calculated.Results The effects of reducing growth speed of the body weight and fat weight and that of lowering IRI in ZTS group were better than those in GCT group(P<0.01),similar to MHT group(P<0.05) and there was dose-effect relationship in lowering IRI.The decreasing effects of Ins,Glu,TG,NEFA and LDL-c were better than those in GCT group(P<0.001),similar to MHT group except for NEFA(P>0.05),which showed that the effect of decreasing NEFA in ZTS group was better than that in MHT group(P<0.05).Conclusion ZTS has remarkable effect of lowering the insulin resistance in rats with type 2 diabetes mellitus.