吸烟、饮酒与食管癌关系的Meta-分析

Meta-analysis on the Association of Esophageal Cancer with Smoking and Alcohol Drinking

目的探讨我国吸烟、饮酒与食管癌的关系。方法应用 Meta-分析方法对国内有关吸烟、饮酒与食管癌的关系7个研究结果进行定量综合分析。用随机效应模型 (D- L 法 )计算合并比值比 (OR)及其 95 %的可信区间 (95 % CI)。结果吸烟、饮酒的合并 OR分别为 1.84 (95 % CI:1.5 0～ 2 .2 5 )和 1.5 0 (1.2 2～ 1.85 ) ,它们相应的归因危险度百分比分别为2 3.2 1%和 16 .4 1%。结论吸烟、饮酒是我国食管癌的危险因素。

Objective To study the relation between smoking,alcohol drinking and the risk of esophageal cancer in China.Method 7 separated studies on the relation between smoking,alcohol drinking and esophageal cancer in China were analyzed by Meta analysis. Random effect model was selected to calculate the pooled odds ratio ( OR ) and its corresponding 95% confidence interval(95% CI).Result The pooled OR for smoking,alcohol drinking were 1.84(95% CI 1.50～2.25),1.50(1.22～1.85),respectively.The population attributable risks due to smoking and alcohol drinking were 23.21% and 16.41%,respectively.Conclusion Smoking and alcohol drinking are the risk factors for esophageal cancer in China.\;