2-氨基-5-甲基噻唑合成工艺的改进

Improved synthesis of 2-amino-5-methylthiazole

以正丙醇为原料 ,经次氯酸氧化、氯代、硫脲环合得到美洛昔康关键中间体 2 氨基 5 甲基噻唑 ,该法操作简单 ,收率高 ,成本低 ,总收率为 5 5 %。

2-Amino-5-methylthiazole,a key intermediate for the synthesis of meloxicam,was prepared from n-propanol by oxidation and chlorination with hypochlorous acid,followed by condensation with thiourea in an overall yield of 55%.