2-乙酰噻吩吖嗪及其过渡金属配合物的合成与活性

Synthesis and the bio-activities of 2- acetyl-thiophen azine and its new complexes of Fe ^(3+),Cu^(2+)

目的研究 2 乙酰噻吩吖嗪及其过渡金属Cu2 + ,Fe3 + 配合物的合成与生物活性。方法从2 乙酰噻吩和水合肼出发合成 2 乙酰噻吩吖嗪 ,进而合成了其过渡金属Cu2 + ,Fe3+ 的配合物。用MS ,1H NMR对配体进行了确认。通过元素分析、摩尔电导率、红外光谱、紫外光谱等手段对配合物进行了表征。用NBT法研究了配合物对超氧阴离子自由基的抑制作用 ;并利用MTT法和SRB法对其进行了抗肿瘤活性体外筛选实验。结果发现配体和配合物都具有一定的生物活性 ,且Cu配合物活性较好。结论配合物的生物活性可能与中心离子的最外层d轨道的电子结构有关。

Aim To study on the bioactivities and syntheses of 2-acetyl-thiophen azine and its new complexes containing Fe 3+,Cu 2+.Method 2-Acetyl-thiophen azine was synthesized from 2-acetyl-thiophen and hydrazine,and its complexes were synthesized by refluxing 2-acetyl-thiophen azine and corresponding metal salts.The ligand has been characterized by 1H-NMR spectra and MS spectra.The compositions and structures of complexes have been characterized by the elemental analysis,IR spectra and UV spectra.The free radical ( O 2 ·) inhibition rate has been tested by the NBT method.Their bioactivities against cancer in vitro have been tested by the MTT method and RB method.Results Both ligand and complexes have bioactivities,and the activity of Cu complexes is the best.Conclusion Activities of complexes may depend on the structure of outermost d-orbital electron.