精神分裂症认知障碍与精神症状的关系

A study of cognitive deficit and its correlation with mental symptoms

目的:探索精神分裂症认知障碍特点及其与阴性、阳性症状间的关系。 方法:比较32例未用过抗精神病药的精神分裂症患者及15例正常受试者的事件相关电位(ERPs)和威斯康星卡片分类测验(WCST)成绩,并进行相关分析。 结果:精神分裂症患者多个位点N2和P3波潜伏期延长,P3波幅降低。WCST中分类完成数偏少,持续错误数和总错误数增加。N2潜伏期和波幅与阳性症状与阴性症状量表(PANSS)阳性症状分呈负相关,而WCST总错误数与PANSS总分和阴性症状分正相关。 结论:精神分裂症病人存在中枢信息处理障碍、认知障碍,与阴性、阳性症状之间具有一定的内在联系。

Objective:To study the cognitive deficit and its relationship to mental symptoms. Method:32 schizophrenics who were drug naive or drug-free for at least two weeks were compared with 15 healthy controls in the event-related potentials (ERPs) and Wisconsin card sorting test (WCST) profiles. Patients were also measured with positive and negative symptom scale (PANSS). Results: Compared with controls, schizophrenics manifested longer N2 and P3 wave latency, lower P3 amplitude in several site and lower WCST performance such as decreased categories achieved and increased total errors and perseverative errors. Patients' cognitive deficit have some correlation with negative and positive symptoms. Conclusion:There may be information processing deficit in central nervous system of schizophrenics. Patients' cognitive deficit have some correlation with negative and positive symptoms.