精神分裂症血清神经元特异性烯醇化酶研究

Study on neuron specific enolase in serum of patients with schizophrenia

目的:探讨精神分裂症患者血清神经元特异性烯醇化酶(NSE)的变化及其临床意义。 方法:对62例精神分裂症患者于入院后次日、第3个月末采取血液标本进行NSE测定,并与61名健康人进行对照。 结果:精神分裂症患者发病期间血清NSE含量明显高于对照组,治疗3个月后显著下降,且与阳性症状与阴性症状量表(PANSS)总分的降低呈显著相关性。 结论:精神分裂症患者发病期间,血清NSE含量增高,可能与精神病理学改变有关,且与精神病性症状有关。

Objective: To study the changes of neuron specific enolase (NSE) in serum of patients with schizophrenia and its clinical significance. Method:Blood specimens were collected from sixty-two schizophrenia patients on the second day and the end of the third month after admission. NSE contents were determined and compared with sixty-one normal controls. Results: NSE contents in serum of patients were significantly higher than those in controls. The results also showed a remarkable reduction of NSE contents of patients after being treated for three months, which positively correlated with the total scores of PANSS scale of the patients. Conclusion: Schizophrenia patients had high NSE contents in serum,which may be correlated with changes of psychopathological and psychiatrical symptoms of patients.