皮下脂膜炎性T细胞性淋巴瘤P-gp、LDH和β_2-MG测定及其临床分析

Determination and clinical significance of P-gp expression, serum latic dehydrogenase and β_2-microgtobulia inSPTCL

目的 研究皮下脂膜炎性T细胞性淋巴瘤(SPTCL)的临床特点以及初步探讨P-糖蛋白(P-gp)、血清乳酸脱氢酶(LDH)和β2-微球蛋白(β2-MG)在SPTCL中的临床意义及其预后价值。方法观察12例SPTCL的临床特点,用免疫组织化学法检测8例SPTCL患者P-gp,采用速率法及放免法分别测定8例SPTCL,10例对照的LDH、β2-MG。结果 12例SPTCL患者中女性9例,年龄小,确诊时间长,预后差,另8例患者LDH、β2-MG明显高于对照组(P<0.05),其中3例P-gp阳性的LDH、β2-MG也高于5例P-gp阴性的患者。结论 对可疑SPTCL患者应尽早行皮肤活检以确诊,SPTCL预后差可能与其P-gp阳性率较高,LDH、β2-MG增高有关。

Objective To study clinical feature of SPTCL and discuss clinical significance of P-gp, LDH and B2-MG in SPTCL.Method To summarize clinical feature of 12 patients with SPTCL;P-gp expression,serum LDH and B2-MG in 8 SPTCL patients were determined by immunohistochemical, speed-ratio method and radioimmu-noassy technique.Result There were 9 female patients in 12 SPTCL and their average age were 28.6 years old, the duration from episode to diagnosis was long, and they had bad prognosis. The serum level of LDH and B2-MG were higher in 8 SPTCL than those in normal group significantly. The serum level of LDH and B2-MG in 3 postive P-gp patients were higher obviously than that in other 5 negative P-gp patients. Conclusion SPTCL had a bad prognosis, this might be correlated with increased postive P-gp ratio, higher serum level of LDH and ft-MG. Patients considered SPTCL should be given cutaneous pathologic examination as early as possible.