染色体异态性与早期生殖障碍

Chromosome Heteromorphism and Early Reproduction Inability

目的:探讨染色体异态性与早期生殖障碍的关系。方法:采用G、C显带染色体核型分析等方法,比较染色体异态核型人群和正常核型人群的早期生殖障碍的发生率。结果:染色体异态组早期生殖障碍率高达45.7％,明显高于染色体正常组(10.6％),二者比较具有高度显著性差异。1、9和16号染色体长臂次缢痕增长的异态类型引起的早期生殖障碍发生率较高,均在50％以上。结论:染色体异态与早期生殖障碍存在明显的关系,染色体异态可能导致早期生殖障碍。

Objective:To investigate, the relationship between chromosome , hetermorphism and early reproduction inability. Methods: The incidence rates of early reproduction inability of chromosome heteromorphism group and normal kary-otype group were compared by using G, C-banded chromosome karyotype analysis. There were 45.7% people with reproduction inability in heteromorphism group and 10. 6% people with repro- duction inability in normal karyotype group. There was significant difference between two groups. The incidence rates of early reproduction inability were more than 50% in people with long arm constitutive increasing of chromosome 1,9 and 16. Results: There was corelation between chromosome heteromorphism and reproduction inability. The chromosome heteromorphism maybe resulted in reproduction inability. Conclusion: The result has denied the traditional opinion that the chromo-sorne heteromorphism is no harmful to organism. The heteromorphisms can affect the cell division and result in developing abnormality of early embryo.