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用毛细管电泳技术对北京汉族人群9个STR基因座遗传多态性的研究 被引量：1

A Study Using Capiliary Electrophoresis in Genetic Polymorphism of 9 STR Loci in Han Population of Beijing
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摘要 为对北京汉族D3S135 8、vWA、FGA、D8S1179、D2 1S11、D18S5 1、D5S818、D13S317及D7S82 0等 9个STR基因座的遗传多态性进行群体遗传学研究 ,利用荧光标记复合扩增及毛细管电泳自动荧光检测的方法 ,对2 36名无关个体获得 9个STR基因座等位基因的分布频率 ,结果均符合Hardy Weinberg平衡 .计算了各基因座的杂合度 (H)、个人识别能力 (DP)、偶合率 (PM )、非父排除率 (EPP)和多态性信息总量 (PIC)等群体遗传学数据 .结果表明 ,这 9个STR基因座多态性好 ,灵敏度高 ,可用于人类遗传分析及法医学中的亲子鉴定和个人识别 . Totally 236 unrelated individuals from majority population of Han Chinese in Beijing have been inspected with 9 polymorphism STR loci D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820 by means of capillary electrophoresis and fluorescence multiple amplification. The results indicated a good correspondence with the Hardy-Weinberg equilibrium. Observed heterozygosity, expected heterozygosity, DP, PM, EPP, and PIC were calculated for evaluation of forensic application.
作者 裴黎 王俭 季安全 荣辽江 王海生 邓华
机构地区 公安部第二研究所 内蒙古自治区公安厅 湖北省公安厅
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2003年第1期147-150,共4页 Progress In Biochemistry and Biophysics
关键词 毛细管电泳技术 北京汉族人群 STR基因座 遗传多态性 群体遗传学 capillary electrophoresis short tandem repeat multiplex amplification population genetics
分类号 Q987 [生物学—遗传学] Q347 [生物学—遗传学]
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参考文献8

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共引文献31

同被引文献24

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生物化学与生物物理进展
2003年 第1期

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