异丙酚对肢体缺血再灌注损伤的影响

Effect of propofol on lesion after limb ischemia-reperfusion

目的 :探讨异丙酚对肢体缺血 /再灌注损害的影响。方法 :对 3 0例 (异丙酚组 15例 ,对照组 15例 )使用止血带患者测其血中丙二醛 (MDA)、谷胱甘肽 (GSH)含量变化。结果 :两组病人各时段血中MDA含量均显著升高 (P <0 .0 1) ,GSH含量均显著降低 (P <0 .0 1)。II组缺血 /再灌注后同一时段内MDA显著低于I组(P <0 .0 1)。II组缺血 /再灌注后 3 0min、60min与I组同一时间段相比GSH显著升高 (P <0 .0 1) ,90min时 ,GSH与I组同一时间段相比显著增高 (P <0 .0 5 )。结论 :在再灌注同时或再灌注之前 ,给予异丙酚 。

Objective:To investigate appropriate antioxidation anaesthetic propofol which can prevent organization from peroxidative injury.Methods:Serum MDA GSH in 30 cases including control group(n=15) and observed group(n=15) were measured. Results:A significant serum MDA increase and GSH decrease were seen at reperfusion 30,60,90 min compared with the pre ischemia value in the control group and the observed group(P<0.01). In the observed group the serum MDA value was significantly lower than that of the control group after 30,60,90 min reperfusion (P<0.01). GSH activity increased gradually in the observed group and evidently higher than the value of the control group after 30,60 min reperfusion (P<0.01) and a litter higher at reperfusion 90 min(P<0.05).Conclusion:Propofol can reduce peroxidative injuries in clinical relevant concentration.