不同水平抑制肾素-血管紧张素系统对大鼠肾脏增龄性改变的影响

Effects of RAS inhibition at different sites on aging kidney of rats

目的 研究长期抑制 RAS对老龄大鼠肾脏的保护作用。方法 观察福辛普利钠及缬沙坦对老年大鼠肾脏病理、纤维连接蛋白(FN)、纤溶酶原激活物抑制剂 (PAI- 1 )及转化生长因子 (TGFβ- 1 )基因表达的影响。结果 两组治疗均可降低老年大鼠的尿蛋白 ,减少肾小球细胞外基质 (ECM)面积、减轻肾小球硬化及肾小管间质损害 ;下调肾脏 FN、PAI- 1的基因表达 ,对 TGFβ- 1 m RNA的表达无影响 ,福辛普利钠与缬沙坦治疗效果无明显差异。结论 长期抑制 RAS可减轻老年肾损害 ,血管紧张素转换酶抑制剂 (ACEI)与血管紧张素 受体拮抗剂 (AT1 RA)具有相同的作用。

Objective To identify renal protective benefits of chronic angiotensin blockade on aged rats. Methods To study the effects of fosinopril or valsartan on the pathological changes, genes expression of fibronectin(FN), plasminogen activator inhibitor- 1 (PAI-1) and transforming growth factor(TGFβ-1) in aged kidney of male Wistar rats. Results Either fosinopril or valsartan could decrease urine protein significantly. Extracellular matrix (ECM) expansion, glomerulus sclerosis, and tubules interstitial lesion were ameliorated in treatment groups. Gene expressions of FN and PAI-1 in renal cortex were down-regulated markedly, although therapies for each group showed no significant effects on TGFβ-1 mRNA. No differences between the renal protective effects of fosinopril and valsartan could be detected. Conclusions Long-term inhibition of RAS can ameliorate aging-related renal lesion. There are no differences in the protective effects between ACEI and AT 1RA.