赛庚啶对大鼠血清性激素含量的影响

Effects of Cyproheptadine on Serum Sex Hormones Concentrations in Rats

目的 研究赛庚啶 (CYP)对大鼠血清性激素含量的影响。方法 用放射免疫分析法 (RIA)观察赛庚啶对大鼠垂体 性腺轴内分泌功能的影响。结果 赛庚啶 (2 .3mg·kg-1·d-1,灌胃 ,14d)可明显升高雌性大鼠血清LH的水平 (P <0 .0 5 ) ,降低其卵泡刺激素 (FSH)、孕酮 (P)的含量 (P <0 .0 1) ;对雄性大鼠血清黄体生成素(LH)、FSH、睾酮 (T)的含量均无显著影响。赛庚啶 (4.6mg·kg-1·d-1,灌胃 ,14d)可明显升高雄性大鼠血清LH ,T的含量 (P <0 .0 5 ) ,而对FSH无显著影响 ;同时可显著升高雌性大鼠血清LH的含量 (P <0 .0 5 ) ,降低其FSH ,P ,E2的含量 (P <0 .0 1)。结论 赛庚啶可促进雌雄大鼠LH及雄性大鼠T分泌 ,抑制雌性大鼠FSH ,E2 ,P的分泌 ,对雄性大鼠FSH分泌无显著影响 ,且存在性别差异。

Objective To study the effects of Cyproheptadine(CYP) on serum sex hormone concentrations in rats.Methods The hormone concentrations were measured with radioimmunoassay(RIA).Results It was found that CYP(2.3 mg·kg -1 ·d -1 ,ig,14d) increased serum LH concentration and decreased serum P concentration in female rats significantly(P<0.05,P<0.01,respectively),but had no effects on serum LH,FSH,T concentrations in male rats and serum E 2 concentration in female rats. CYP(4.6 mg·kg -1 ·d -1 ,ig,14d)could increase serum LH,T concentrations while having no effect on FSH concentration in male rats,but increased serum LH concentration(P<0.05) while decreased serum FSH,E 2 and P concentrations significantly(P<0.01) in female rats.Conclusion Cyproheptadine has stimulative effects on serum LH(♀♂),T(♂) concentration but inhibitory effects on serum FSH,P,E 2 concentration in female rats.